老年人抗胆固醇药物暴露的时间趋势:一项为期25年的基于人口的研究
Amanda Evelo1,2, Silvan Licher3,4, Bruno H Stricker3
1Department of Hospital Pharmacy, Erasmus MC, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.
Drug safety
|June 27, 2025
概括
自1996年以来,老年人的抗胆固醇药物暴露量下降了50%以上. 然而,老年人仍然面临最高的风险,需要在处方方面保持警.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 抗胆固醇药物暴露与老年人的不良结果有关.
- 建议限制抗胆固醇负担 (ACB),但人口层面的趋势数据很少.
- 这项研究分析了社区居住的老年人中ACB的时间趋势.
研究的目的:
- 估计累计ACB分数为3或以上 (cACB ≥3) 的累计发病率和发病率 (IR).
- 在一个社区居住的老年人群中,在25年内描述cACB≥3的IR变化.
- 为了确定老年人抗胆固醇药物暴露的趋势.
主要方法:
- 使用了基于人口的鹿特丹研究 (1996-2020) 的药房发行记录.
- 使用抗胆固醇认知负担量表和EPHOR专家建议计算cACB分数.
- 确定特定于年龄和性别的IR,并使用5年周期分析时间趋势.
主要成果:
- 从1996年到2020年,cACB≥3的累积发病率为25.3%,为1996年至2020年的25.3%.
- 在1996-2000年至2016-2022年期间,cACB ≥3的发病率下降了54%.
- 86-90岁的个人与66-70岁的人相比,cACB≥3的IR是cACB≥3的1.67倍.
结论:
- 在1996年至2020年期间,社区居住的老年人中,抗胆固醇药物暴露显著减少了50%以上.
- 最年长的个体始终表现出cACB≥3的最高风险.
- 对抗胆固醇药物处方的持续审查至关重要,特别是在脆弱的老年人群中.
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