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配方开发和描述含有黄素的比格尔,用于局部皮肤输送

Lord Sam Liston¹, Suranate Phanapithakkun^1,2, Nuttakul Pimsarn¹

¹School of Pharmacy, Walailak University, 222 Thaiburi, Nakhon Si Thammarat, 80161, Thasala, Thailand.

AAPS PharmSciTech

|June 27, 2025

概括

这项研究开发了一种新的黄素大配方 (BG30),以改善黄素.

科学领域:

皮肤病学和制药科学皮肤病学和制药科学
材料科学与工程材料科学与工程

背景情况:

黄素表现出有益的皮肤特性,如抗炎和伤口愈合.
皮肤透率较低限制了黄素的局部疗效.
比格尔,结合水凝和有机凝的特性,提供增强的交付系统.

研究的目的:

为了改善局部输送,制定和表征含有黄素的大面包.
为了评估皮肤沉积,安全性和伤口愈合潜力.

主要方法:

使用HPMC水凝和Span® 60/杏仁油机凝制备了黄大片 (BG50,BG40,BG30).
比格尔的特点是物理特性,皮肤透性和体外细胞毒性.
使用小鼠纤维细胞细胞系 (L929) 划伤试验评估了伤口愈合的有效性.

主要成果:

BG30配方显示了局部输送的最佳特征.
与organogel相比,BG30显著增强了皮肤层中的黄素积累.
所有的大豆都是无毒的,BG30表现出优越的伤口愈合能力.

结论:

开发的BG30大配方有效地增强了黄素的皮肤沉积和治疗潜力.
BG30显示出作为治疗皮肤疾病和促进伤口愈合的库尔库明局部输送系统的前景.

关键词:

在Bigels的手机上,我们可以看到Bigels.库尔库明是一种黄素.穿透皮肤穿透皮肤局部药物输送是目前的药物输送.

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