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Updated: Sep 17, 2025

Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
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T细胞分化阶段阻断偏差在T细胞淋巴细胞淋巴瘤中赋予了高甲基化和中原偏好

Jiali Wang1, Bo Qian2, Xiaowen Yu3

  • 1Department of Hematology and Oncology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Clinical and translational medicine
|June 28, 2025
PubMed
概括

这项研究揭示了T细胞急性淋巴细胞白血病 (T-LBL) 和T细胞急性淋巴细胞白血病 (T-ALL) 是同一疾病的不同阶段,T-LBL细胞在DN和DP阶段被阻止. 脱甲基化疗法通过准UHRF1-介导的高甲基化,有效地抑制T-LBL的扩散.

关键词:
T细胞分化的阶段T细胞分化的阶段在T细胞淋巴细胞淋巴瘤.过甲基化过度的发生.介质的偏好 介质的偏好

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