血清生物标志物用于早期检测死亡性肠球炎:系统性审查
Sara Pimenta1, Susana Pissarra2, Paulo Soares1,2
1Faculty of Medicine, University of Porto, Porto, Portugal.
Journal of perinatal medicine
|June 28, 2025
概括
肠脂肪酸结合蛋白 (I-FABP) 在早产婴儿中显示出早期检测死性肠球炎 (NEC) 的前景. 需要进一步的研究来验证I-FABP和缺血修饰性白蛋白 (IMA) 等生物标志物的临床用途.
科学领域:
- 新生儿医学 新生儿医学
- 胃肠病学 胃肠病学
- 生物标志物研究 生物标志物研究
背景情况:
- 结核性肠球炎 (NEC) 是早产婴儿的严重疾病,死亡率高.
- 由于非特异性症状和延迟的放射学发现,早期的NEC诊断是困难的.
研究的目的:
- 审查关于血清生物标志物的证据,以早期检测NEC.
- 评估生物标志物的诊断准确性和临床实用性.
主要方法:
- 40项研究的系统审查.
- 在 MEDLINE,Scopus 和 Web of Science 上进行了搜索.
- 评估了各种生物标志物类别.
主要成果:
- 肠脂肪酸结合蛋白 (I-FABP) 是早期NEC预测的一个有前途的生物标志物.
- 缺血变异性白蛋白 (IMA) 和多标记面板也显示出高精度.
- 研究的局限性包括小样本大小和异质性.
结论:
- I-FABP和IMA显示了早期NEC检测的潜力.
- 需要进行多中心研究来验证生物标志物并确定切断点.
- 生物标志物整合可能会改善NEC诊断和结果.
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