高部内垂体向药物输送用于耐火性神经病性面疼痛
Shyam A Desai1, Harold W Burke2, Adejuyigbe O Adaralegbe1
1Division of Pain Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
概括
在一系列患者中,高部通道内药物输送有效地管理了耐火性神经病性面疼痛. 这种治疗方案可显著减轻疼痛,即使是对其他疗法耐药的复杂病例.
科学领域:
- 神经学 神经学
- 疼痛管理 疼痛管理
- 神经外科 神经外科
背景情况:
- 由于异质性,神经性面疼痛综合征存在诊断和管理方面的挑战.
- 这些疾病往往对传统的医疗和干预治疗不耐药.
- 有限的文献存在于高部内药物输送用于神经病性面疼痛.
研究的目的:
- 评价高内导药物输送系统 (IDDS) 在耐火性神经病性面疼痛患者的疗效和安全性.
- 描述以前多次治疗失败的患者的结果.
主要方法:
- 对12名耐火性非癌症神经病性面疼痛患者的回顾性图表审查,这些患者接受了高部IDDS治疗.
- 患者已经失败了各种医疗,干预和神经调节疗法.
- 数据包括疼痛严重程度,药物剂量,并发症和长期随访.
主要成果:
- 在12名患者中,有9名患者在芬太尼/布皮瓦卡因组合后经历了超过50%的疼痛改善.
- 平均疼痛严重程度在数值评分尺度上显著下降,从9.5降至4.3 (p < 0.01).
- 没有患者因疗效丧失而停止治疗;三人需要导管修复迁移.
结论:
- 高度的宫内导药物输送是耐火性神经病性面疼痛的可行治疗方法.
- 这种方法即使在患有不同疼痛病因和治疗失败的患者中也是有效的.
- IDDS为具有挑战性的面疼痛病例提供了潜在的解决方案.
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