与血清丸激素总量相比,计算的自由丸激素与老年男性的肌肉质量,肌肉力量,功率和身体功能有更强烈的关联
Kristian Villars Lolck1,2, Julian Alcazar3,4,5, Rikke Stefan Kamper3,6
1Department of Geriatric and Palliative Medicine, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark. kristian.kaltoft.lolck@regionh.dk.
Aging clinical and experimental research
|June 28, 2025
概括
计算的自由,而不是总,与老年男性的肌肉健康和身体功能更为密切相关. 这一发现对于理解与年龄相关的肌肉质量和力量变化至关重要.
科学领域:
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
- 运动医学 运动医学
背景情况:
- 低血清丸激素与老年男性肌肉质量和力量的减少有关,但研究是不一致的.
- 了解不同测量的作用对于男性衰老研究至关重要.
研究的目的:
- 为了比较总和计算的自由与年轻人与老年男性的肌肉状况之间的关系.
- 为了确定哪种测量最好与不同年龄组的肌肉质量,力量和身体表现相关.
主要方法:
- 557名健康的丹麦男性 (年龄在23-92岁之间) 被评估身体组成 (BMI,脂肪百分比,ALM,ALM%,SMI),肌肉力量 (HGS,LEP) 和身体表现 (30秒STS).
- 测量了总血清丸激素,SHBG和白蛋白;计算了自由丸激素和FTI.
- 一般线性模型和聚合效应模型分析了测量和肌肉参数之间的关联,以及年龄组相互作用.
主要成果:
- 总丸激素与身体表现有混合的关联 (年轻男性的30岁STS为负,年长男性的LEP为阳性).
- 计算的自由丸激素与老年男性的腿部力量 (LEP),骨肌肉指数 (SMI),肌肉质量百分比 (ALM%),手握力 (HGS) 和坐立性能 (30-s STS) 有积极的关联.
- 计算的自由丸激素和FTI,与总丸激素不同,与老年男性的复合肌肉得分有积极的联系.
结论:
- 计算的自由丸激素与老年男性的肌肉状况和身体表现比总丸激素更显著地相关.
- 这些发现强调了评估自由的重要性,以评估老年男性的肌肉健康.
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