慢性胰腺炎患者的大麻使用和结果:全国住院患者样本分析
Aalam Sohal1, Nuhar Thind2, Harbir Singh Billing3
1Department of Internal Medicine, Tristar Centennial Medical Center, Nashville, TN, USA. aalamsohal@gmail.com.
Journal of gastrointestinal and liver diseases : JGLD
|June 28, 2025
概括
慢性胰腺炎患者使用大麻与更好的结果有关,包括较低的死亡率和更少的并发症. 这表明大麻素可能在控制胰腺炎的严重程度方面发挥作用.
科学领域:
- 胃肠道学和肝病学
- 药理学 药理学 是一个学科.
- 公共卫生 公共卫生
背景情况:
- 大麻表现出抗炎和止痛的特性,先前的研究表明在胰腺炎中具有潜在的益处.
- 慢性胰腺炎 (CP) 是一种致残的疾病,需要进一步研究有效的管理策略.
研究的目的:
- 研究大麻使用对慢性胰腺炎住院患者临床结果的影响.
- 分析大麻消费与CP患者各种不良事件和死亡率之间的关联.
主要方法:
- 利用2016-2020年全国住院患者样本 (NIS) 数据库,确定诊断为慢性胰腺炎的患者.
- 根据大麻使用情况对患者进行分层,收集人口统计数据,并发病 (查尔森并发病指数) 和关键结果.
- 采用多变量逻辑回归来分析大麻使用与败血症,AKI,DVT,PE,ICU入院,AP,胰腺癌和死亡率等结果之间的关系.
主要成果:
- 对907790名患者的分析显示,5.8%的人是大麻使用者.
- 大麻使用与降低死亡率 (aOR=0.47),DVT (aOR=0.71),PE (aOR=0.622),ICU入院 (aOR=0.705) 和胰腺癌 (aOR=0.730) 的几率显著相关.
- 在大麻使用者和非使用者之间,没有观察到AKI,败血症或急性胰腺炎的几率有显著差异.
结论:
- 患有慢性胰腺炎住院患者的大麻使用与疾病严重程度降低和改善结果有关.
- 需要进一步的研究来验证这些发现,并阐明大麻素在治疗胰腺炎中的特定作用.
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