在女性同性伴侣中,怀孕并发症与受孕方法有关吗? 一个回顾性,匹配的队列研究
Sara Loreti1, Margot Moeykens2, Ezgi Darici3
1UZ Brussel, Brussels IVF, Brussels, Belgium.; Genera Veneto, Generalife IVF, Marostica, Italy..
Reproductive biomedicine online
|June 28, 2025
概括
同性伴侣使用来自伴侣的卵细胞接收 (ROPA) 的女性同性伴侣的怀孕可能与子宫内授精 (IUI) 相比,具有更高的早产和子宫前的风险. 咨询应解决这些潜在的产科风险,特别是在冷胚胎移植后.
科学领域:
- 生殖医学 生殖医学
- 产科 产科 产科 产科 产科
- 在LGBTQ+健康方面
背景情况:
- 女性同性伴侣经常利用辅助生殖技术来受孕.
- 从伴侣那里接收卵细胞 (ROPA) 和子宫内授精 (IUI) 是常见的方法,但它们的比较安全概况尚未完全理解.
- 了解与不同的概念方法相关的风险对于明智的决策至关重要.
研究的目的:
- 为了比较女性同性伴侣通过ROPA怀孕的妊娠高血压疾病 (HDP) 和其他不良周产期结局的风险与IUI.
- 在ROPA中确定可能影响怀孕风险的特定因素或治疗方式.
主要方法:
- 一个回顾性,单中心,匹配的队列研究,对577名2015年1月至2023年1月期间怀孕的女性同性伴侣进行了研究.
- 根据年龄,BMI,平价和转移/输精日期,匹配了73例ROPA怀孕和77例IUI怀孕.
- 对比HDP的发病率,孕前,早产,第一季度出血和新生儿结局.
主要成果:
- 在ROPA和IUI之间,总体HDP/孕前率没有显著差异.
- 在ROPA怀孕中,早产前的发病率明显较高 (P=0.04),特别是在人工制备的冷胚胎移植后 (P=0.04).
- 在ROPA怀孕中,早产和第一季度出血的发病率较高 (P=0.002).
结论:
- ROPA可能与产科风险增加有关,包括早产和早产前,特别是人工制备的冷胚胎移植.
- 这些发现对于为女同性恋夫妇提供关于怀孕方法和潜在风险的咨询至关重要.
- 进一步的研究可能是有必要的,以探索这些观察到的差异背后的机制.
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