在前代谢综合征或没有前代谢综合征的药物原始精神分裂症中,炎症和认知功能之间的关系
Qiao Su1, Jiayue Wang1, Hongmin Ge1
1Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China.
Psychiatry research
|June 28, 2025
概括
前代谢综合征 (pre-MetS) 与精神分裂症 (SCZ) 的认知功能恶化有关. 炎症标志物不同于它们与SCZ患者的认知障碍的相关性,无论是否有前-MetS.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 炎症与精神分裂症 (SCZ) 的认知功能有关.
- 代谢前综合征 (pre-MetS) 对这种关系的影响尚未被探索.
- 这项研究研究了在未服用过药物的SCZ患者中,MetS前期,炎症和认知功能之间的关系.
研究的目的:
- 检查前代谢综合征 (前代谢综合征) 和前不用药物精神分裂症 (SCZ) 患者的认知功能之间的关系.
- 探索炎症标志物在SCZ患者的认知障碍中的差异性作用,有或没有预先MetS.
主要方法:
- 对228名以前没有服用过药物的SCZ患者进行了横截面研究,分为预先MetS和非预先MetS组.
- 代谢和炎症标志物的测量:空腹血葡萄糖 (FPG),胆固醇 (CHO),甘油三 (TG),高密度脂蛋白 (HDL),低密度脂蛋白 (LDL),C反应蛋白 (CRP),CRP-白蛋白比率 (CAR) 和中性粒细胞-淋巴细胞比率 (NLR).
- 使用 MATRICS 共识认知电池 (MCCB) 评估认知功能;用于探索关系的部分相关性分析.
主要成果:
- 与非前MetS组相比,前MetS组的患者在五个认知功能维度上显示出显著的差异 (P <0.05).
- 在MetS前组中,FPG,TG,HDL和NLR与认知功能相关 (P <0.05);HDL和NLR组合预测认知障碍 (AUC = 0.712).
- 在非pre-MetS组中,CRP和CAR与认知功能相关 (P <0.05);CRP和CAR组合预测认知障碍 (AUC = 0.744).
结论:
- 前代谢综合征与精神分裂症中更大的认知障碍有关.
- 显著的炎症机制是SCZ患者的认知障碍的基础,无论是否有前-MetS.
- 研究结果强调了新陈代谢状态在理解精神分裂症认知缺陷方面的重要性.
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