多发性硬化症患者的主观认知功能:与客观认知功能,焦虑,抑郁和疲劳的关联
Bonnie I Glanz1, Isaiah Kletenik2, Tarun Singhal1
1Department of Neurology, Harvard Medical School, Boston, MA, United States of America; Brigham MS Center, Brigham and Women's Hospital, Boston, MA, United States of America.
Journal of the neurological sciences
|June 28, 2025
概括
在患有多发性硬化症 (pwMS) 的人群中,自我报告的认知问题与疲劳,焦虑和抑郁症比客观认知测试更相关. 对这些因素的查是解释认知缺陷的关键.
科学领域:
- 神经学 神经学
- 神经心理学 神经心理学
- 康复医学 康复医学 康复医学
背景情况:
- 在患有多发性硬化症 (pwMS) 的人群中,认知障碍很普遍,影响他们的生活质量.
- 自我报告的认知功能与pwMS中的客观测量之间的关系仍然不清楚.
研究的目的:
- 在pwMS中调查主观认知功能与客观认知表现之间的关联.
- 确定焦虑,抑郁和疲劳对 pwMS 中自我报告认知功能的影响.
主要方法:
- 分析了345个pwMS的数据,包括客观认知测试 (符号数字模式测试,加利福尼亚语音学习测试-II) 和主观测试 (神经质量认知功能,焦虑,抑郁,疲劳).
- 多变量回归模型被用来评估主观认知功能与客观测量之间的关系,控制心理和疲劳变量.
主要成果:
- 主观认知功能最初与客观测试,焦虑,抑郁和疲劳有关.
- 在多变量分析中,自我报告的认知功能与客观处理速度 (SDMT) 或口头学习 (CVLT-II) 没有关联.
- 疲劳,焦虑和抑郁是pwMS中自我报告认知功能的显著独立预测因素.
结论:
- 在pwMS中自我报告的认知功能与心理因素 (焦虑,抑郁) 和疲劳比客观认知缺陷更强烈相关.
- 在pwMS中自我报告的认知困难的临床解释应该考虑对焦虑,抑郁和疲劳进行查.
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