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在患有扩散性大B细胞淋巴瘤的患者中,循环的粘膜相关的不变T细胞减少并功能受损

Jingru Liu¹, Jiadi Chen², Shucheng Chen³

¹Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, China.

Translational oncology

|June 28, 2025

概括

循环粘膜相关的不变T细胞 (MAIT) 在扩散性大B细胞淋巴瘤 (DLBCL) 患者中显著减少和功能障碍,损害抗瘤免疫力,并与预后不佳相关.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

粘膜相关不变T细胞 (MAIT) 在瘤免疫力中起作用.
在扩散性大B细胞淋巴瘤 (DLBCL) 中,MAIT细胞的功能尚不清楚.

研究的目的:

确定DLBCL患者MAIT细胞的频率和功能特征.
研究MAIT细胞频率与DLBCL的预后之间的关联.

主要方法:

对DLBCL患者的MAIT细胞频率和表型的比较分析与健康对照.
对MAIT细胞细胞因子产生和对DLBCL细胞的细胞毒性进行评估.
在MAIT细胞频率和临床结果之间的相关性分析.

主要成果:

与对照组相比,DLBCL患者的循环MAIT细胞显著减少.
来自DLBCL患者的MAIT细胞表现出衰老和功能障碍的表型,激活/耗尽标记增加 (CD69,CD25,HLA-DR,PD-1,Tim-3).
观察到抗瘤细胞因子 (IFN-γ,IL-17,TNF-α,Granzyme B) 的产生减少,以及对DLBCL细胞的细胞毒性降低.
较低的MAIT细胞频率与DLBCL患者的不良预后相关.

结论:

在DLBCL患者中,循环MAIT细胞减少并功能受损.
这些MAIT细胞缺陷导致抗淋巴瘤免疫力受损.
MAIT细胞频率作为DLBCL的潜在预后标志物.

关键词:

扩散大的B细胞淋巴瘤.功能障碍功能障碍是指一种功能障碍.粘膜相关的不变T细胞预测预测预测预测

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