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Updated: Sep 17, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Published on: January 2, 2015

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对GSK3β酸化介导的tau聚合的药理干预,通过调节富含proline的tau域的相分离来调节tau聚合

Shan Sun1, Siqian Chen1, Junqiu He2

  • 1Faculty of Health Sciences, University of Macau, Taipa, Macau, China; Jiangsu Key Laboratory of Drug Discovery and Translational Research for Brain Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|June 28, 2025
PubMed
概括

异常的蛋白凝结,阿尔茨海默氏症的标志,是由proline丰富域 (PRD) 酸化驱动的. 抑制糖原合成酶激酶3β (GSK3β) 降低了陶凝结,并减缓了疾病的进展.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.凝结凝结的情况在GSK3ββ中.阶段分离 阶段分离 阶段分离富含氨酸的域名 富含氨酸的域名塔乌·塔乌 (Tau Tau) 是一个

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