表达HLA-DR的淋巴结纤维细胞维持FoxP3+调节性T细胞,并在类风湿性关节炎中减少

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Aoife M O'Byrne1,2,3, Cristoforo Grasso1,2,3, Charlotte M de Winde4,5,6

  • 1Amsterdam UMC, Location AMC, University of Amsterdam, Department of Rheumatology and Clinical Immunology, Amsterdam, The Netherlands.

Clinical and experimental immunology
|June 28, 2025
PubMed
概括

人类淋巴结纤维细胞表达HLA-DR维持调节性T细胞,这对周围耐受性至关重要. 在类风湿性关节炎中,这种功能可能会受到损害,这表明自身免疫力发挥了作用.

关键词:
在 HLA-DR 组合下,抗原呈现的呈现方式.自体免疫性是一种自身免疫性.纤维细胞的细胞.淋巴结的淋巴结是指淋巴结的周围的耐受性监管T细胞的监管性T细胞类风湿性关节炎 类风湿性关节炎树皮细胞 树皮细胞

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