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Updated: Sep 17, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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作为一个独特的亚群,等离子体样淋巴瘤细胞在PCNSL中赋予多药性耐药性

Feng Liang1,2, Xiaotao Zhang3, An Ping1,4

  • 1Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Neuro-oncology
|June 28, 2025
PubMed
概括

等离子体样淋巴瘤细胞 (PBLC) 在初级中枢神经系统淋巴瘤 (PCNSL) 中驱动药物耐药性. 准PBLCs分子特征为这种侵袭性脑癌提供了一个新的治疗策略.

关键词:
内异质性 内异质性主要中枢神经系统淋巴瘤多种药物耐药性多种药物耐药性一个单细胞RNA测序.

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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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