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Updated: Sep 17, 2025

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通过使用多基因风险评分在不同人群中探索抑郁症治疗反应

Sandra Lapinska1, Aditya Pimplaskar2, Zhuozheng Shi1

  • 1Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

American journal of human genetics
|June 28, 2025
PubMed
概括

遗传因素影响治疗耐药性抑郁症 (TRD). 较高的大型抑郁症多基因分数 (MDD-PGS) 与祖先的TRD有关,影响抗抑郁药的反应. 这项研究分析了各种生物库的基因洞察力.

关键词:
抗抑郁药对抗抑郁药的反应生物银行是生物银行.多样化的祖先.电子健康记录是电子健康记录.遗传学 遗传学 遗传学 是一个大型抑郁症主要是抑郁症.多基因风险得分的多基因风险得分.与治疗相关的现象型.

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