恒温睡眠中心的时钟依赖调节维持白天睡眠和晚上活动
Cynthia T Hsu1, Camilo Guevara1, Samantha L Killiany1
1Chronobiology and Sleep Institute and Howard Hughes Medical Institute, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Current biology : CB
|June 28, 2025
概括
顺势睡眠中心,像背部风扇形体 (dFSB),通过与昼夜时钟相互作用来调节日常睡眠. 这种相互作用确保睡眠驱动被限制在特定时间,影响白天的午睡和夜间的睡眠开始.
科学领域:
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
- 睡眠研究 睡眠研究
背景情况:
- 恒温睡眠中心在长时间清醒后促进睡眠.
- 这些中心在生理节律调节的日常睡眠中的作用仍然不清楚.
- 调查反弹睡眠电路是否与昼夜睡眠电路重叠至关重要.
研究的目的:
- 为了确定23E10+神经元,包括背面风扇形体 (dFSB),与昼夜时钟相互作用以调节日常睡眠.
- 为了研究反弹睡眠和每日基线睡眠之间的神经生理学差异.
- 了解dFSB在睡眠调节中的日时依赖功能.
主要方法:
- 在Drosophila中观察到睡眠模式和神经元活动.
- 使用体内成像来监测dFSB中的水平.
- 研究了周期基因和色素分散因子 (PDF) 信号在睡眠调节中的作用.
- 研究了沉默dFSB神经元的影响.
主要成果:
- 23E10+神经元,特别是dFSB中的胆神经元,促进白天睡眠 (午睡).
- 在维持白天休息时间方面,DFSB的作用部分取决于时间的变化.
- dFSB水平表现出昼夜节律,在白天的午睡期间达到峰值.
- 丢失PDF信号导致过早的dFSB降低调节和更早的夜间睡眠开始.
- 沉默dFSB可以挽救PDF缺陷突变体夜间睡眠开始的时间.
结论:
- 背面风扇形体 (dFSB),一个恒温的睡眠中心,依靠昼夜时钟来限制睡眠驱动到一天中的特定时间.
- 循环节律调节对于睡眠是必不可少的,甚至对于恒温驱动的睡眠.
- 这些发现阐明了平静和昼夜睡眠机制之间的相互作用.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
01:11Understanding Sleep
515
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
515
01:24Sleep-Wake Cycles
1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.6K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
135
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
135
01:19Management of Insomnia
328
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
328
01:02The Pineal Gland
2.6K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
2.6K