菌病原体促进毛虫的食和体重增加,使用类似宿主的三酶
Peiqing Zhao1, Jianfeng Lin1, Dehong Yang2
1Key Laboratory of Insect Developmental and Evolutionary Biology, State Key Laboratory of Plant Trait Design, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China; CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China.
Current biology : CB
|June 28, 2025
概括
这项研究揭示了Cordyceps真菌如何通过改变宿主荷尔蒙和糖分水平来操纵丝虫的食和体重增加. 这种由寄生虫驱动的行为最终有利于真菌的繁殖和生存.
科学领域:
- 菌类学 菌类学是指菌类学.
- 昆虫病理学 昆虫病理学
- 分子生物学分子生物学
背景情况:
- 寄生虫与宿主之间的相互作用在进化生物学中至关重要.
- 了解改变宿主行为的寄生虫基因对于寄生虫传播至关重要.
- 军用菌 (Cordyceps militaris) 是一种感染和操纵昆虫宿主的昆虫病原菌.
研究的目的:
- 为了研究Cordyceps militaris改变丝虫宿主行为的分子机制.
- 为了确定特定的寄生虫基因,负责诱导宿主食和体重增加.
- 为了阐明这些宿主操纵如何有利于真菌繁殖.
主要方法:
- 在感染的丝虫中进行基因表达分析,重点是氧化和血淋巴三糖.
- 用Cordyceps militaris菌株进行基因工程,以过度表达或破坏特定的基因 (HemaP,trehalase).
- 感染的丝虫的表型分析,包括养行为,体重增加和幼发育.
主要成果:
- 科迪塞普斯感染诱导了丝虫食增加和体重增加,模仿饥饿反应.
- 在受感染的丝虫中观察到氧化HemaP的升高和降低的血淋巴三糖.
- 在C. militaris中对HemaP和一种真菌三酶基因的基因操纵证实了它们在促进宿主体重增加和有益于真菌繁殖方面的作用.
结论:
- 科尔迪塞普斯军事虫通过寄生虫介导的扩展表型促进宿主食和体重增加.
- 这种真菌利用类似宿主的三酶基因来操纵宿主糖水平,并增强自身的繁殖成功.
- 这项研究突出了涉及宿主衍生基因功能的新奇寄生虫操纵机制.
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