多功能棉伤口包裹增强了苦果提取物加载的固体脂质纳米粒子,用于抗菌,抗氧化和抗癌活动
Ibtisam Alali1, Mahmoud A Abdelaziz2, Abdulhadi H Almarri3
1Department of Chemistry, College of Science, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia.
International journal of biological macromolecules
|June 28, 2025
概括
这项研究开发了一种使用苦果提取物 (BAFE) 装载的固体脂质纳米粒子 (SLN) 在棉织物上的新型伤口包裹. 这种先进的敷料具有显著的抗微生物,抗氧化和抗癌特性,促进伤口愈合的速度更快.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 伤口护理 伤口护理
背景情况:
- 传统的伤口包裹往往无法提供足够的抗微生物和抗氧化剂支持,以实现最佳的愈合.
- 氧化应激,微生物感染和组织再生不良是伤口管理的关键挑战.
研究的目的:
- 通过将苦果果提取物 (BAFE) 装载的固体脂质纳米颗粒 (SLN) 纳入棉织物,开发出一种多功能伤口敷料.
- 评估开发的伤口的抗菌,抗氧化,抗菌膜,抗癌和组织再生能力.
主要方法:
- 使用同质化和超声波合成BAFE载荷的SLN.
- 用BAFE装载的SLN处理棉织物.
- 通过抑制区和细菌活力测定来评估抗菌活性.
- 对抗生素膜,抗氧化剂 (DPPH测试) 和抗癌 (A431细胞的细胞毒性测试) 性能的评估.
- 在体外评估纤维细胞迁移和伤口关闭.
主要成果:
- 装有BAFE的SLN对P. aeruginosa,K. pneumoniae,S. aureus和S. epidermidis表现出强大的抗菌活性.
- 包裹显示出显著的抗生素膜活性 (>50%的生物质减少) 和100%的激素清除活性.
- 细胞毒性测试显示,A431皮肤癌细胞的时间依赖抑制.
- 观察到增强的纤维细胞迁移和加速的伤口关闭 (48小时内52.25%).
结论:
- 装有BAFE的SLN处理的棉织物代表了一个有前途的生物相容性伤口包裹,具有多方面的治疗潜力.
- 这种先进的伤口带提供抗菌,抗氧化和抗癌的好处,适用于感染控制和增强组织再生.
- 开发的材料对先进的伤口护理应用具有重大前景.
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