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构建TiO₂@Ag₂O p-n连接点,用于具有增强功效的协同声动力/声热瘤治疗

Zhizi Ma¹, Zhuang Yang¹, Jie Ma¹

¹School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Acta biomaterialia

|June 28, 2025

概括

这项研究开发了一种多孔二氧化@银氧化物 (TiO₂@Ag₂O) 声敏剂,用于增强声动力学和声热疗法. 这种新材料通过在超声波照射下产生反应性氧物种和局部热量,有效地对抗瘤.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

单组分声敏化剂在声动疗 (SDT) 中表现出有限的疗效.
声热疗法 (STT) 为光热疗法提供了一个有前途的替代方案,在透和安全方面具有优势.
对STT机制和影响因素的进一步研究对其进步至关重要.

研究的目的:

开发一个多孔TiO₂@Ag₂O (TA) 纳米配方,用于协同的SDT和STT.
调查p-n异质连接在提高声敏剂性能方面的作用.
探索载体放松和化对STT疗效的影响.

主要方法:

多孔TiO₂@Ag₂O (TA) p-n纳米制剂的合成.
评估TA在超声波 (US) 照射下产生活性氧物种 (ROS) 和热量的能力.
通过诱导细胞亡和局部升温来评估TA的抗瘤作用.

主要成果:

TA纳米配方有效地分离了电子和孔,促进了用于热转换的声子生成.
在美国辐射下,TA显示出增强的ROS产量 (•OH和1O2) 和局部加热.
该研究证实,调整载体放松和增强化效应可以提高STT的疗效,从而产生显著的抗瘤活性.

结论:

多孔p-nTA作为一个有效的sonosensitizer用于结合SDT和STT.
开发的材料通过线粒体损伤和DNA破坏诱导瘤细胞亡.
这项工作突出了量身定制的纳米配方的潜力和对先进的癌症治疗的物理机制的理解.

关键词:

这是一种抗瘤药物.洞化效应洞化效应洞化作用声动力学疗法声动力学疗法声热疗法是一种超热疗法.在 p-n 交叉点上.

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