阿普塔默-药物结合物 (ApDCs):在向癌症治疗和精确瘤学中的变革性方法
Amir Mohammad Zahedi1, Mohammad Pirouzbakht2, Saeed Zanganeh3
1Stem Cells and Regenerative Medicine Innovation Center, Kerman University of Medical Sciences, Kerman, Iran.
International journal of pharmaceutics
|June 28, 2025
概括
阿普塔默-药物联合体 (ApDCs) 提供精确的癌症向和强大的瘤细胞杀伤,副作用较少. 目前正在进行的研究解决了临床使用的挑战,推进了个性化癌症医学.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 胺体是DNA或RNA分子,对目标分子具有很高的特异性和亲和力.
- 传统的癌症疗法往往缺乏特异性,导致非目标效应.
- 阿普塔默-药物合物 (ApDCs) 代表了针对性癌症治疗的新方法.
研究的目的:
- 在精密瘤学中提供一个全面的阿普他默-药物合物 (ApDCs) 综述.
- 探索ApDCs的创新设计,治疗潜力和结合策略.
- 讨论ApDCs临床翻译的挑战和未来方向.
主要方法:
- 系统审查当前的文献在aptamer发现和结合策略.
- 在体开发中分析SELEX技术和生物信息学.
- 对ApDCs的临床前数据和临床试验信息的检查.
主要成果:
- 使用SELEX和生物信息学在aptamer发现方面的突破使有效的ApDC开发成为可能.
- 不同的结合策略,包括共价和基于纳米粒子的方法,增强了瘤药物输送.
- 临床前研究表明,对阿帕特马-杰姆西塔宾和阿帕特马-多克索鲁比辛结合物等ApDCs具有强烈的瘤选择性细胞毒性.
结论:
- 在临床前模型中,ApDC显示出显著的治疗潜力,具有最小的非目标效应.
- 解决稳定性,免疫性和生产等挑战对于临床翻译至关重要.
- 亚体工程和结合策略的进步有望重塑向癌症治疗和个性化医学.
更多相关视频
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
16.8K
09:56A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
811
相关概念视频
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Tumor Immunotherapy
667
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
667
Targets for Drug Action: Overview
7.5K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
7.5K
Cancer Vaccines
517
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
517
