在患有早期精神分裂症的青少年中,甲状腺皮层结构连接的不平衡
Yonghui Xiang1, Shuting Chen1, Jinqiang Zhang1
1Department of Clinical Psychology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.
甲状腺皮质回路中的结构性连接不平衡存在于早期精神分裂症 (EOS) 中,并反映功能缺陷. 这些变化,特别是涉及中部前额叶皮质的变化,可能解释青少年精神病的不同症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发育神经科学的发展神经科学.
背景情况:
- 甲状腺皮层电路失衡是已知的成年精神分裂症的一个特征.
- 以前的研究表明,在早期发病的精神分裂症 (EOS) 中存在功能性甲状腺皮质电路失衡.
- 这项研究调查了结构连接是否是EOS中观察到的功能失衡的基础.
研究的目的:
- 为了检查早期精神分裂症 (EOS) 的青少年中thalamocortical电路的结构连接性.
- 为了确定结构连接缺陷是否与EOS的症状严重程度相关.
- 探索青少年精神病的神经发育基础.
主要方法:
- 概率性通道图被用来量化212名青少年 (145名EOS患者,67名对照) 的结构连接性.
- 泰拉木斯和14个双边皮层区域被分析为种子和目标.
- 患者被分为未使用药物和接受药物治疗的子组,以控制药物效应.
主要成果:
- 在EOS患者中,与背侧前额皮层 (dlPFC) 和顶层皮层 (parietal cortices) 的thalamic连接性下降.
- 在EOS.中观察到与感觉运动皮层的thalamic连接性增加.
- 意想不到的是,在EOS中发现中部前额叶皮层 (mPFC) 与丘脑的连接性增加,与症状负担相关.
结论:
- 青少年精神分裂症的功能性甲状腺皮质电路失衡得到了类似的结构连接性改变的支持.
- 一个新发现的thalamocortical结构超连接性涉及mPFC在EOS可能解释独特的临床特征.
- 这些发现强调了神经发育模型对于理解青少年精神病的相关性.
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