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IL-8多态 (-251T/A, -1633T/C) 和它们对COVID-19临床结果的影响:一项观察性研究

HariOm Singh¹, Josna Wilson¹, Goldi Namdev¹

¹Department of Molecular Biology, National AIDS Research Institute, Pune, 411026, India.

Microbial pathogenesis

|June 28, 2025

概括

干白素-8 (IL-8) 基因的遗传变异,特别是-251T/A 多态,与COVID-19严重程度的增加有关. 某些IL-8基因型也可以预测患者的血小板缺血和功能障碍等结果.

科学领域:

免疫遗传学免疫遗传学
病毒学病毒学
基因组学就是基因组学.

背景情况:

COVID-19表现出广泛的临床表现,从无症状到危急疾病.
严重的COVID-19通常以细胞因子风暴为特征,涉及高水平的促炎细胞因子.
互乐素-8 (IL-8) 基因多态可能会影响SARS-CoV-2感染中的个体易感性和疾病严重程度.

研究的目的:

研究IL-8基因多态 (-251T/A和+1633T/C) 与COVID-19易感性和严重性之间的关联.
探索这些多形态与临床结果的相关性,包括血小板计数和功能.

主要方法:

一项涉及200名COVID-19患者和201名健康对照者的病例控制研究.
使用聚合酶链反应-限制片段长度多态 (PCR-RFLP) 进行IL-8多态 (-251T/A和+1633T/C) 的基因定型.

主要成果:

IL-8 -251TA基因型和 -251A等位基因与COVID-19显著相关.
IL-8 -251TA基因型与COVID-19严重程度的所有阶段相关,而-251AA基因型与关键阶段相关.
+1633 TT基因型与血小板计数受损有关, +1633CT与严重的COVID-19有关.
-251AA基因型显示出与血清肌氨酸水平升高的边界关联.

结论:

IL-8 -251T/A多态性是严重的COVID-19进展的潜在危险因素.
+1633 TT基因型可能与血小板缺血和不良临床结果有关.
-251AA基因型可能与肌素升高和功能障碍的风险增加有关.

关键词:

在CRP中使用CRP.临床结果临床结果 2019年新冠病毒病的疾病.IL-8 多态性多态性血小板计数血小板计数血小板计数血清中的肌氨酸.

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