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使用介酶干细胞治疗膝关节骨关节炎的生殖动脉栓塞:一项前性研究

Hossein Ghanaati¹, Maedeh Rouzbahani², Jafar Golzarian³

¹School of Medicine, Tehran University of Medical Science, Tehran, Iran; Advanced Diagnostic and Interventional Radiology Research Center, Tehran University of Medical Science, Tehran, Iran.

Journal of vascular and interventional radiology : JVIR

|June 28, 2025

概括

用介质干细胞进行生殖关节动脉栓塞是膝关节关节炎 (OA) 的安全和可行的治疗方法. 这种新疗法在12个月内显著改善了患者的治疗结果和疼痛评分.

科学领域:

再生医学是一种再生医学.
干预性放射学干预性放射学
整形外科整形外科整形外科

背景情况:

膝关节骨关节炎 (OA) 是一种常见的退行性关节疾病,导致严重的疼痛和残疾.
目前治疗膝关节骨质炎的方法存在局限性,需要新的治疗方法.

研究的目的:

评估使用介质干细胞 (MSCs) 进行生殖关节动脉栓塞 (GAE) 的可行性和安全性,用于双侧膝关节OA.
评估GAE与MSC在改善疼痛和功能方面的临床疗效.

主要方法:

30名双侧膝关节骨质炎患者接受了单侧GAE,并将700万个MSC注入生殖关节动脉.
技术成功,安全性 (不良事件) 和临床结果 (VAS,WOMAC) 被评估了12个月.
用MRI成像进行手术前和后的评估;对方未经治疗的膝盖作为对照.

主要成果:

100%的技术成功率为GAE与MSCs.
仅报告了轻微的,短暂的不良事件 (2SIR等级1),没有后续并发症.
在12个月后,WOMAC评分 (29.6至4.6) 和VAS疼痛评分 (6.8至2.0) 的显著改善 (P < .001).

结论:

使用介质干细胞进行生殖关节动脉栓塞是膝关节OA的安全和可行的程序.
这种创新的治疗方法显示出作为一种新的治疗选择来管理膝关节骨关节炎症状并改善关节功能.

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相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...