对癌症患者的系统冠状动脉风险评估2 (SCORE2) 和SCORE2-老年人的外部验证
Mari Nordbø Gynnild1,2, Joris Holtrop3, Steven H J Hageman3
1Department of Circulation and Medical Imaging, Faculty of Medicine and Health Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
心脏瘤学指南建议CVD风险模型,但SCORE2和SCORE2-OP需要在癌症患者中进行验证. 再校准改进了SCORE2 的性能.
科学领域:
- 心脏瘤学是一门专业.
- 心血管疾病风险预测预测
- 癌症患者管理 癌症患者管理
背景情况:
- 在ESC心脏瘤指南中,建议使用SCORE2和SCORE2-OP.对癌症患者进行心血管疾病 (CVD) 风险分层.
- 现有的风险模型缺乏验证和针对癌症群体的具体适应.
研究的目的:
- 改进SCORE2和SCORE2-OP模型,以准确预测癌症患者10年内心血管疾病风险.
- 改善瘤护理中的心血管风险分层.
主要方法:
- 利用了HUNT3研究 (2006-2008) 参与了1622名癌症患者,追踪到2023年.
- 评估心肌梗塞 (MI),中风或心血管疾病死亡率作为主要结局.
- 使用预期观察到的 (E/O) 比率重新校准了SCORE2和SCORE2-OP,并使用哈雷尔的C统计学评估了性能.
主要成果:
- SCORE2最初低估了心血管疾病风险 (E/O比:男性0.91,女性0.63).
- 再校准改善了SCORE2与观察到的心血管疾病风险的一致性.
- 在SCORE2中,C-统计达到0.693 (0.730不包括早期死亡);在SCORE2-OP中,C-统计为0.586和0.648.
结论:
- SCORE2模型低估了癌症患者心血管疾病的风险.
- 再校准的SCORE2显示出在这个人群中作为心血管风险分层的有价值工具的潜力.
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