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系统性硬化患者白质超强度的分布:一个单中心,横截面磁共振成像研究

Shihan Xu¹, Xinyu Tong², Huilin He¹

¹Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Rheumatology (Oxford, England)

|June 28, 2025

概括

系统性硬化症 (SSc) 患者表现出更多的白质超强度 (WMH),特别是在大脑深层区域. 在SSc亚型之间也观察到WMH分布的差异,这表明了不同的疾病模式.

科学领域:

神经学神经学
放射学放射学是一门学科.
类风湿病学类风湿病学

背景情况:

系统性硬化症 (SSc) 是一种影响连接组织的自身免疫性疾病.
白质高强度 (WMH) 是大脑小血管疾病的指标,分为周周血管 (PVH) 和深层 (DWMH).

研究的目的:

量化分析WMH特征和SSc患者与健康对照患者的分布.
为了比较SSc亚型 (dcSSc和lcSSc) 之间的WMH模式.
在SSc.中探索WMH,认知功能和情绪状态之间的关联.

主要方法:

在84名SSc患者和30名健康对照人群中进行了脑磁共振 (MR) 影像.
WMH的数量被细分和量化.
通过逻辑回归和统计测试收集和分析了临床数据,实验室测试和规模结果.

主要成果:

与HC相比,SSc患者的WMH患病率更高,DWMH的比例明显更高.
在SSc亚型之间观察到明显的WMH分布模式,在分散皮肤SSc (dcSSc) 患者中,PVH/WMH比例较高.
在WMH体积比率和认知或情感尺度结果之间没有发现显著的相关性.

结论:

SSc患者更容易患WMH,特别是在深白质区域.
在分散皮肤SSc (dcSSc) 和有限皮肤SSc (lcSSc) 患者中,WMH分布模式似乎不同.
需要进一步的研究,以了解WMH在SSc.中的临床影响.

关键词:

磁共振成像技术的使用系统性硬化症系统性硬化症白质超强度是白质的超强度.

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