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综合奥米克分析根据昼夜节律来定义肝细胞癌的亚型

Xiao-Jie Li¹, Le Chang¹, Yang Mi¹

¹Henan Key Laboratory for Helicobacter pylori and Digestive Tract Microecology, the Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China; Institute of Rehabilitation Medicine, Henan Academy of Innovations in Medical Science, Zhengzhou 450000, Henan Province, China; Tianjian Laboratory of Advanced Biomedical Sciences, Zhengzhou University, Zhengzhou 450000, Henan Province, China.

Journal of integrative medicine

|June 28, 2025

概括

肝细胞癌 (HCC) 中的循环节律扰乱 (CRD) 定义了三种亚型. 较高的CRD得分与更差的预后相关,使HCC患者能够个性化治疗策略.

科学领域:

在瘤学瘤学.
时间生物学时间生物学
基因组学就是基因组学.

背景情况:

循环节律扰乱 (CRD) 与肝细胞癌 (HCC) 的预后不佳有关.
在HCC中CRD的潜在机制在很大程度上仍未定义.
了解基于CRD的HCC异质性对于改善患者的治疗结果至关重要.

研究的目的:

根据昼夜节律扰乱 (CRD) 来分类肝细胞癌 (HCC) 亚型.
探索这些定义的HCC亚型之间的分子和临床异质性.
确定潜在的生物标志物,用于预测CRD的HCC患者的预后.

主要方法:

开发了HCC CRD得分 (HCCcrds) 来量化昼夜节律扰乱.
利用机器学习识别CRD模块基因并定义HCC亚型.
应用生物信息学分析已识别的CRD相关HCC亚型的细胞异质性.

主要成果:

确定了三种不同的HCC亚型,具有显著的预后异质性.
高HCCcrds亚型显示出更糟糕的预后,更高的病理等级,和高级阶段.
低HCCcrds亚型显示出更好的临床结果,发现了新的生物标志物.

结论:

将HCC患者分为三个基于昼夜节律的不同组,具有独特的生物标志物.
在这些亚型中,高HCCcrds和更差的预后之间建立了相关性.
提出了一种新的方法,以改善HCC预后预测和精确治疗指导.

关键词:

循环节律的破坏循环节律的破坏肝细胞癌亚型肝细胞癌亚型俄米克斯 (Omics) 是一个电子游戏.个性化治疗个性化治疗精确的医学是精确的医学.

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