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脊髓MRI在检测非复发性进展性多发性硬化症患者的活跃疾病中的附加值
Marco Vercellino1, S Marasciulo2, C Bosa3,2
1Multiple Sclerosis Center, Neurologia 1 U, Department of Neuroscience, AOU Città della Salute e della Scienza di Torino, Via Cherasco 15, 10126, Turin, Italy. marco.vercellino@unito.it.
Journal of neurology
|June 28, 2025
概括
将脊髓MRI添加到脑MRI中,可以在更多非复发性渐进性多发性硬化症 (pMS) 患者中检测出活跃疾病. 这有助于预测治疗反应和指导治疗选择.
科学领域:
- 神经学 神经学
- 放射学 放射学是一门学科.
- 神经免疫学 神经免疫学
背景情况:
- 脊髓MRI并不是常规用于监测多发性硬化症 (MS).
- 渐进性多发性硬化 (pMS) 的疾病活动预测了治疗反应.
- 在非复发性PMS中识别活跃疾病对于治疗决策至关重要.
研究的目的:
- 评估脊髓MRI在检测非复发性PMS患者的活跃疾病中的附加值.
- 为了评估脊髓MRI是否改善了与单独脑MRI相比,疾病活动的识别.
主要方法:
- 从pms患者的mri扫描的回顾性审查,至少2年的随访.
- 在随访期间包括没有临床复发的患者.
- 无症状组合独特活跃病变 (CUA) 的定义是没有临床复发的新的T2/STIR或T1 Gd+病变.
主要成果:
- 分析了185名没有复发的PMS患者 (41名初级进展,144名二级进展).
- 15.1%的患者出现了新的无症状CUA脑损伤,7.6%出现了新的无症状CUA脊髓损伤.
- 脊髓MRI检测到43.75%的患者比单独脑MRI的患者更多的疾病活动.
结论:
- 结合脊髓MRI显著增加了在非复发性PMS中检测活跃疾病的率.
- 这种增强的检测有助于对患者进行分层,以预期治疗反应.
- 脊髓MRI发现可以为PMS患者提供信息和个性化治疗选择.
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