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相关概念视频

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Sample Handling01:02

Sample Handling

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Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...
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Semiconductors01:22

Semiconductors

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There is variation in the electrical conductivity of materials - metals, semiconductors, and insulators that are showcased with the help of the energy band diagrams.
Metals such as copper (Cu), zinc (Zn), or lead (Pb) have low resistivity and feature conduction bands that are either not fully occupied or overlap with the valence band, making a bandgap non-existent. This allows electrons in the highest energy levels of the valence band to easily transition to the conduction band upon gaining...
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Hepatic Portal System01:21

Hepatic Portal System

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The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
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Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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iChip01:24

iChip

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The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
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相关实验视频

Updated: May 4, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
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从肝脏在芯片平台中吸取的经验教训

Zahra Sadat Razavi1,2, Fateme Sadat Razavi3, Madjid Soltani4,5,6,7,8

  • 1Physiology Research Center, Iran University Medical Sciences, Tehran, Iran.

Annals of biomedical engineering
|June 28, 2025
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概括
此摘要是机器生成的。

实验性肝脏模型的进步,从2D培养到3D系统和芯片上的肝脏 (LioCs),通过模仿肝脏微环境,更好地了解肝脏疾病和药物查.

关键词:
在体外模型模型.肝脏新陈代谢 肝脏的新陈代谢肝脏在芯片上的肝脏器官在芯片上的器官

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科学领域:

  • *肝病学和体外建模
  • * 生物医学工程和组织工程.

背景情况:

  • *肝脏在新陈代谢中的中心作用需要准确的体外模型进行研究.
  • *传统的二维肝脏模型缺乏自然肝脏环境的三维复杂性.
  • * 2D模型的局限性阻碍了对肝脏病理生理学的准确研究.

研究的目的:

  • * 审查实验性肝脏模型的演变.
  • *强调3D肝培养策略和芯片上的肝脏 (LioCs) 的发展.
  • *强调疾病和药物研究的新模型的改善生理相关性.

主要方法:

  • * 讨论传统的2D肝细胞模型.
  • * 探索先进的3D肝脏培养技术.
  • *分析芯片上的肝脏 (LioCs) 结合流体动力学.

主要成果:

  • * 3D模型更好地复制肝脏的细胞相互作用和微环境.
  • *芯片上的肝脏 (LioCs) 模拟生理流体流动,增强肝功能.
  • * LioCs在病理生理学建模,组织工程和药物查方面具有显著的实用性.

结论:

  • *从二维到三维和LioC模型的进展代表了模仿肝脏体内环境的重大飞跃.
  • *高级模型对于准确的肝病研究和有效药物开发至关重要.
  • * LioCs为高通量,生理相关的肝脏研究提供了一个强大的平台.