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年轻和老年周血管脂肪组织对内皮功能和炎症的亲衰老和再生效应

Chak Kwong Cheng¹, Xingtao Huang², Shuhui Meng²

¹Department of Biomedical Sciences and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong, 999077, China. superandy333@gmail.com.

|June 28, 2025

概括

衰老的周周脂肪组织 (PVAT) 加快了血管衰老,而年轻的PVAT提供了一些保护. 这突出了脂肪血管轴作为心血管衰老干预的目标.

科学领域:

心血管科学心血管科学
衰老研究研究衰老研究
脂肪组织生物学脂肪组织生物学

背景情况:

血管衰老与内皮功能障碍,炎症,氧化应激和端粒问题有关.
周血管脂肪组织 (PVAT) 调节血管功能,但随着年龄的增长而出现功能障碍,增加心脏代谢疾病的风险.
以前的研究表明,老年PVAT可能会损害血管功能.

研究的目的:

调查老年和年轻的PVAT是否在小鼠中促进或减缓血管衰老.
确定不同年龄组PVAT对大动脉内皮功能的影响.
探索PVAT对血管衰老的影响背后的机制.

主要方法:

从年轻和老老的小鼠与年轻和老年捐赠者的PVAT共培养PVAT无动脉48小时.
评估内皮依赖放松 (EDRs) 使用线性肌肉学.
分析血管氧化应激,炎症,端粒功能和AMPK/SIRT1信号传递.

主要成果:

老年PVAT损害了内皮功能,增加了氧化应激和炎症,并在年轻的大动脉中抑制了AMPK/SIRT1信号传递.
年轻的PVAT部分缓解了内皮功能障碍,并逆转了老年大动脉的有害影响.
增长分化因子15 (GDF15) 和炎症性细胞因子部分介导了这些PVAT效应.

结论:

PVAT显著调节内皮功能和血管衰老.
脂肪血管轴是心血管衰老的潜在治疗点.
PVAT的年龄相关性质影响血管健康,为与年龄有关的心血管疾病提供了洞察力.

关键词:

衰老的衰老衰老的衰老内皮细胞内皮细胞的内皮细胞.脑内皮功能脑内皮功能炎症炎症是一种炎症.氧化应激是一种氧化应激.周周血管脂肪组织

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