在患有高血压的患者中,动脉硬与心房合和左心房相位功能有关
Jinling Liu1, Xiaolin Mu2, Yang Song2
1Department of Cardiology, Central Hospital of Dalian University of Technology, Dalian, People's Republic of China.
American journal of hypertension
|June 29, 2025
概括
高血压引起的动脉硬会损害左心房功能和动脉合. 腕脉冲波速度 (baPWV) 预测了这种心脏损伤,改善了高血压患者的风险评估.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 高血压研究 高血压研究
背景情况:
- 高血压 (HTN) 是动脉硬 (AS),左心房 (LA) 和左心室 (LV) 功能障碍的主要危险因素.
- 脉冲波速率 (PWV) 的增加,这是AS的衡量标准,可以对LA相位功能产生负面影响.
研究的目的:
- 在高血压患者中调查脚PWV (baPWV),左心房合指数 (LACI) 和LA相位功能之间的关联.
- 评估baPWV对基本高血压中LA功能障碍的预测价值.
主要方法:
- 招募了150名基本高血压患者的前性队列,并根据中位数的baPWV进行了分层.
- 进行了跨组比较,相关性分析和接收器运行特征 (ROC) 曲线分析.
- 使用多变量线性回归调整心血管风险因素.
主要成果:
- 患有较高baPWV的患者表现出较低的LA喷射分数 (LAEFtotal,LAEFpass),缩应变 (εs) 和透缩应变 (εe),以及较高的LACI.
- 在风险因素调整后,baPWV与LA最小体积指数 (LAVImin),LACI,e和e独立相关.
- 将baPWV与传统风险因素结合在一起,显著改善了LACI,LAVImin,eS和eE的预测性能.
结论:
- 高血压介导的动脉硬与LA-动脉和LA-LV-动脉合的同时异常有关.
- 将baPWV纳入风险分层模型可以更好地预测高血压中临床前心脏目标器官损伤.
相关概念视频
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
59
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
59
Hypertension II: Pathophysiology
90
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
90
Hypertension III: Clinical Manifestations and Diagnostic Studies
58
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
58
Aortic Regurgitation I: Introduction
45
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
45
Aortic Regurgitation III: Medical Management
52
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
52
Mitral Stenosis I: Introduction
48
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
48


