随着年龄的增长和来自升高的异原体指数的风险:甘油三 (TG) 与高密度胆固醇 (HDL-C) 的比例
Manish Kumar1,2,3, Shangshu Zhao4, Peter Robinson2
1Division of Cardiovascular Medicine, Marshfield Clinic, Marshfield, Wisconsin, USA.
Journal of the American Geriatrics Society
|June 29, 2025
概括
动脉质指数,即甘油三和高密度胆固醇的比率,显示随着个体年龄的增长,与动脉样硬化心血管疾病 (ASCVD) 风险的相关性下降. 在65岁以上的成年人中,较高的动脉动脉生成指数甚至可能与发生ASCVD的风险降低相关.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 老年学是一门学科.
背景情况:
- 低密度脂蛋白胆固醇 (LDL-C) 与动脉样硬化心血管疾病 (ASCVD) 有关,但随着年龄的增长,这种联系会减弱.
- 甘油三 (TG) 与高密度脂蛋白胆固醇 (HDL-C) 的比率,或动脉动脉指数,是小密度LDL-C (sdLDL-C) 的标志物,是一种特定的ASCVD生物标志物.
研究的目的:
- 调查年龄的增长如何影响动脉动脉生成指数和发生ASCVD之间的关联.
- 评估升高的动脉动脉生成指数和年龄对ASCVD风险的综合影响.
主要方法:
- 对没有先前ASCVD和可用的脂质生物标志物的英国生物库参与者的分析.
- 使用非线性考克斯回归来建模年龄对TG:HDL-C五分位数和事件ASCVD的影响.
主要成果:
- 较高的TG/HDL-C比率 (五分位数2-5) 与65岁以上的ASCVD风险增加有关.
- 高TG/HDL-C比率与ASCVD风险之间的关联随着年龄的增长而减少 (Q5和Q1的HR分别为45岁,55岁和65岁的HR分别为1.60,1.37和1.07).
- 发展ASCVD的个体年龄较大,平均TG/HDL-C比较高.
结论:
- TG/HDL-C比率与发生的ASCVD之间的关联随着年龄的增长而减弱.
- 在65岁以上的成年人中,TG/HDL-C比率升高可能与ASCVD风险降低有关.
- 这些与年龄相关的变化可能反映了代谢风险的改变或需要进一步研究的生存效应.
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