患有自闭症谱系障碍的儿童的周周血管空间负担与神经发育严重程度相关
Giulia Frigerio1, Gloria Rizzato1, Denis Peruzzo2
1Diagnostic Imaging and Neuroradiology Unit, IRCCS Scientific Institute E. Medea, Bosisio Parini, Lecco, Italy.
Journal of magnetic resonance imaging : JMRI
|June 29, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童的周血管空间 (PVS) 与脑脊液 (CSF) 容量和临床严重程度有关. 额头区域的PVS数量较高,时间区域的PVS数量较低.
科学领域:
- 神经成像是一种神经成像.
- 发育神经科学的发展神经科学.
- 自闭症谱系障碍研究研究
背景情况:
- 大脑周血管空间 (PVS) 促进大脑脊髓液 (CSF) 的循环和废物清除.
- 在自闭症谱系障碍 (ASD) 中观察到增加的PVS,但它们与CSF动态和疾病严重程度的关联仍然不清楚.
研究的目的:
- 用磁共振成像 (MRI) 量化评估被诊断为ASD的儿童的PVS.
主要方法:
- 对66名患有自闭症儿童 (平均年龄4.7岁) 的回顾性分析,使用3T MRI与3D T1加权的GRE和3D T2加权的旋回转回声序列.
- 使用弱监督的算法对PVS进行细分,分析整个白质区域的总计数 (WM-PVStot) 和正常化体积 (WM-PVSvoln).
- 统计分析包括肯德尔相关性和弗里德曼测试,一般化的线性模型评估了PVS,发育系数 (DQ),临床严重程度和外轴性CSF (eaCSF) 体积之间的关系.
主要成果:
- 较高的WM-PVStot计数与严重的DQ,较轻的ASD形式和较大的eaCSF体积有显著的关联.
- WM-PVSvoln主要受到正常化eaCSF体积 (eaCSFvoln) 的影响.
- 细分白质PVS (WM-PVSsr) 的百分比在前额区域最高 (32%),在部区域最低 (11%).
结论:
- 患有自闭症儿童的PVS数量和体积与eaCSF体积,临床严重程度和DQ相关.
- 在区域内,PVS的分布有所不同,前额白质的流行率较高,时间区域的流行率较低.
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