纳米颗粒嵌入的GelMA/NIPAm水凝:一种温度响应的混合系统,用于控制药物释放
Maria Daaboul1, Ayse Akkaya2, Zehra Kanli3
1Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, Turkey.
Macromolecular bioscience
|June 29, 2025
概括
这项研究开发了一种使用GelMA/NIPAm水凝和含氨酸的PLGA纳米颗粒来控制药物输送的新型温度响应水凝系统. 该系统显示了高效,温度敏感的药物释放应用的有前途潜力.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 药物输送系统 药物输送系统
背景情况:
- 温度敏感的水凝提供由环境变化引发的受控释放.
- 聚合物纳米粒子提高了药物封装和输送效率.
- 结合这些技术可以创建先进的药物输送平台.
研究的目的:
- 开发一种新型的温度响应药物递送系统,使用GelMA/NIPAm水凝和含氨酸的PLGA纳米粒子.
- 描述开发系统的物理化学特性,胀行为,药物释放动力学和生物相容性.
- 评估该系统在高效和温度敏感的药物输送方面的潜力.
主要方法:
- 用素 (PHT) 装载的多D,L-乳酸-协同甘化物 (PLGA) 纳米颗粒的制备和表征.
- 凝甲基烯基/N-异甲基胺 (GelMA/NIPAm) 含有PHT-PLGA纳米颗粒的水凝的制造和特征.
- 使用FTIR,SEM,DSC,XRD,DLS,胀测试,药物释放研究和细胞活力测试进行评估.
主要成果:
- 装有药物的纳米粒子具有223.7nm的水力动力直径和负泽塔电位.
- 水凝呈现出温度依赖的胀,随着温度的增加而下降 (25°C的9.0到40°C的6.0).
- 观察到持续的 fenytoin 释放,在升高的温度下释放的更高 (在 40°C 时 ~ 34%,在 37°C 时 ~ 20% 在 7 天内).
- 细胞活力测定没有显示出细胞毒性和细胞增殖的潜力.
结论:
- 开发的GelMA/NIPAm水凝系统有效地结合了带有PHT的PLGA纳米粒子.
- 该系统表现出显著的温度反应性胀和受控的药物释放特性.
- 这种水凝平台显示出对高效,温度敏感和受控的药物输送应用程序的承诺.
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