阿司匹林与胃癌风险之间的剂量反应关系:系统性审查和元分析
Shan Zhang1, Hongwei Wang1, Jingjing Ji1
1Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
Cancer epidemiology
|June 29, 2025
概括
阿司匹林的使用可能会降低胃癌的风险,更高的剂量显示出更大的保护作用. 这种剂量反应关系表明阿司匹林在预防胃癌方面具有潜力,特别是在亚洲人群中.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃癌是全球癌症死亡的主要原因之一.
- 作为循环氧化酶抑制剂的阿司匹林正在研究其在胃癌中潜在的化学预防作用.
- 阿司匹林摄入量与胃癌风险之间的确切剂量-反应关系尚未明确定义.
研究的目的:
- 系统地审查和元分析队列研究,以澄清阿司匹林使用和胃癌风险之间的剂量反应关系.
- 评估不同的阿司匹林剂量对胃癌发病率的影响.
- 探索阿司匹林化学预防作用的潜在区域差异.
主要方法:
- 在2014年1月1日至2024年1月1日期间发表的队列研究,在PubMed,Embase和Web of Science进行了系统的文献搜索.
- 来自六项符合条件的研究的数据,包括超过150万参与者,被汇总为元分析.
- 统计分析包括相对风险计算和剂量反应建模,根据地区进行子组分析.
主要成果:
- 在阿司匹林剂量和胃癌风险之间发现了显著的反向关联 (RR 0.73;95% CI:最高与最低剂量的0.57-0.94).
- 剂量反应分析表明存在非线性关系,更高的阿司匹林剂量与更大程度的胃癌风险降低相关.
- 亚组分析显示,亚洲人群的保护作用更强,这表明区域异质性.
结论:
- 这项研究提供了强有力的证据,支持使用的阿司匹林剂量与患胃癌的风险之间的关联.
- 较高的阿司匹林剂量在降低胃癌风险方面似乎更有效.
- 这些发现强调了阿司匹林在胃癌化学预防方面的潜在效用,并为未来的研究和临床策略提供了信息,特别是考虑到区域差异.
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