在农业健康研究中使用卡巴里尔和发生癌症:更新的分析分析
Patricia A Erickson1, Gabriella Andreotti2, Richard V Remigio2
1Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
概括
卡巴里尔杀虫剂的使用与农药应用器中胃,食道,舌头和侵袭性前列腺癌的风险增加有关. 这项大型研究突出了潜在的癌症关联,需要进一步研究生物机制.
科学领域:
- 流行病学 流行病学
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 碳酸盐杀虫剂,包括carbaryl,在美国被广泛使用.
- 以前的研究表明,卡巴里尔暴露与癌症风险之间存在潜在联系.
- 农业健康研究 (AHS) 是对北卡罗来纳州和爱荷华州农药应用者的前性队列研究.
研究的目的:
- 评估在持许可的农药应用者中与卡巴里尔使用相关的癌症风险.
- 根据常用和强度加权寿命日 (IWLD) 评估卡巴里尔暴露的风险.
- 通过滞后暴露分析来调查潜在的关联.
主要方法:
- 对52,625名农药施用者进行前性队列研究.
- 在入学期间 (1993-1997) 和随访期间 (1999-2005) 收集的关于终身农药使用的数据.
- 通过国家癌症登记处确定癌症发病率;Poisson回归用于估计速率比率 (RR) 和置信区间 (CI),控制混因素和评估滞后暴露.
主要成果:
- 大约51%的申请者报告使用卡巴里尔.
- 增加卡巴里尔IWLD与更高的胃癌风险相关 (RR T3 = 2.07),持续与5年的暴露滞后 (RR T3 = 2.20).
- 观察到食道 (RR = 1.52) 和舌头 (RR = 1.91) 癌症的风险增加,经常使用,以及具有30年暴露滞后的侵袭性前列腺癌 (RR lag30Q4 = 1.56).
结论:
- 这项全面的前性研究提供了新的证据,将卡巴里尔暴露与增加特定癌症的风险联系起来,包括胃癌,食道癌,舌头癌和侵袭性前列腺癌.
- 这些发现表明需要进一步的研究来证实这些关联,并了解潜在的生物机制.
- 这项研究是迄今为止对前性队列中卡巴里尔和癌症风险的最大评估.
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