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雾化特兰胺酸用于控制小儿桃体切除术后出血
Macaulay Ojeaga1, Antonio Bon Nieves1, Andrea Nguyen2
1Kansas University Medical Center, Kansas City, KS, 66103, USA.
International journal of pediatric otorhinolaryngology
|June 29, 2025
概括
雾化松酸 (TXA) 显著减少了手术干预的必要性在患有桃体切除术后出血的儿科患者. 这项研究发现,雾化TXA是一种安全有效的治疗选择,可以控制桃体切除术后的出血.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 桃体切除术后出血 (PTH) 是儿科患者常见的并发症.
- 有效的静血控制对于尽量减少发病率和医疗保健成本至关重要.
- 目前对PTH的管理策略各不相同,需要评估新的治疗方案.
研究的目的:
- 评价雾化松酸 (TXA) 在治疗儿科桃体切除术后出血的疗效和安全性.
- 确定与需要在PTH手术静血控制相关的因素.
- 为了比较用和没有雾化TXA治疗的患者之间的结果.
主要方法:
- 从2019年1月到2023年10月,对患有PTH的儿科患者 (<18岁) 的回顾性图表审查.
- 收集的数据包括患者人口统计,临床表现,治疗方式 (雾化TXA,手术对照),停留时间和再入院率.
- 进行了统计分析,以比较TXA和非TXA组之间的结果,并确定手术干预的预测因素.
主要成果:
- 总共有287名患者被分析;100人接受了雾化TXA.
- TXA组的手术干预率明显较低 (26.0%与41.7%相比,p=0.010).
- 雾化TXA将需要手术的几率降低了75% (OR=0.25,p<0.001),没有报告的并发症. 停留时间和再接收率在各组之间是相似的.
结论:
- 雾化胺酸 (TXA) 是一种有效和安全的辅助疗法,用于控制儿科桃体切除术后的出血.
- 在PTH中,TXA的使用可能会显著降低手术干预的必要性.
- 需要进一步的前性研究来证实这些发现并建立最佳方案.
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