在慢性囊炎中评估尿道微生物群,基于中流尿样.
Margarita Boldyreva1, Maria Petrunicheva2, Anastasia Ivanova2
1NRC Institute of Immunology, Federal Microbiological Agency, Moscow, Russian Federation.
Urologia internationalis
|June 29, 2025
概括
尿路感染 (UTI) 和慢性囊炎显示出改变的细菌特征. 基因组DNA和Lactobacillus spp. 这样的关键标记物. 这些水平可以帮助诊断这些尿路疾病.
科学领域:
- 微生物学 微生物学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 分子诊断学 分子诊断
背景情况:
- 尿路感染 (UTI) 很常见,慢性复发性囊炎对健康构成重大挑战.
- 了解尿路微生物群对于诊断和管理尿路疾病至关重要.
研究的目的:
- 为了比较健康妇女的尿道微生物群,有尿路感染风险的妇女和患有慢性复发性囊炎的妇女.
- 为了确定尿路疾病的潜在分子诊断标记物.
主要方法:
- 多重实时PCR被用于分析尿样.
- 研究了三组患者:健康对照组,慢性复发性囊炎患者和患有尿路感染风险的个人.
主要成果:
- 慢性囊炎表现出增加的总细菌质量 (TBM) 和基因组DNA,其中 fakultative 厌氧生物如 Escherichia coli 和 Serratia marcescens 主导.
- 在尿路感染风险患者中发现基因组DNA和无氧微生物的增加.
- 风险组和慢性囊炎组都显示了乳杆菌种类的减少,在慢性囊炎中更明显.
结论:
- 基因组DNA,TBM和乳杆菌种类. 这些水平作为有价值的分子诊断标记.
- 这些标记物可以帮助诊断慢性囊炎,微神经病和细菌性阴道炎.
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