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Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
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Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
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Updated: Sep 17, 2025

Open-source Single-particle Analysis for Super-resolution Microscopy with VirusMapper
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使用放大MS2病毒样颗粒进行货物装载和表面显示.

Antonina Naskalska1, Marta Walczak2, Agnieszka Dąbrowska1

  • 1Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387 Krakow, Poland.

International journal of pharmaceutics
|June 29, 2025
PubMed
概括

修改的菌体MS2病毒样颗粒 (VLPs) 被扩大并功能化,用于双重外部和内部有效载荷传递. 这些增强的VLP显示了哺乳动物免疫细胞的有效吸收,突出显示了它们的疫苗和药物输送潜力.

关键词:
抗原消解器可以消解抗原.货物装载 货物装载细胞输送 细胞输送在MS2细菌菌体中.类似病毒的粒子.

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科学领域:

  • 生物技术是生物技术.
  • 纳米技术 纳米技术
  • 免疫学 免疫学 免疫学

背景情况:

  • 菌体MS2病毒样颗粒 (VLPs) 被用于疫苗和药物输送.
  • 之前的工作表明MS2 VLPs可以修改为更大的颗粒组装.

研究的目的:

  • 在外部和内部展示扩展的MS2 VLP的功能.
  • 评估哺乳动物免疫细胞对这些修改后的VLP的吸收.

主要方法:

  • 利用SpyTag-SpyCatcher技术进行SARS-CoV-2 RBD的外部附着.
  • 封装的光标记的寡度氧核酸和内部的mRNA.
  • 研究哺乳动物免疫细胞的吸收.

主要成果:

  • 在扩大的MS2 VLP上成功实现了SARS-CoV-2 RBD的外部功能化.
  • 已经证明了核酸 (oligodeoxynucleotides和mRNA) 的内部封装.
  • 已证实免疫细胞有效吸收装饰/装载扩大的MS2 VLPs.

结论:

  • 扩大的MS2 VLP可以在外部有效地装饰,并在内部有效地加载.
  • 这些功能化的VLP在疫苗和药物输送应用中表现出有前途的特性.
  • 免疫细胞的增强吸收支持其在免疫疗法和向治疗中的潜力.