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在人类下降胸前大动脉中通过雪崩传播解剖:衰老的影响

Ruizhi Wang¹, Xunjie Yu¹, Samuel C Halvorsen¹

¹Department of Mechanical Engineering, Boston University, Boston, MA 02215.

Acta biomaterialia

|June 29, 2025

概括

衰老通过改变原纤维结构来削弱大动脉剖析阻力,导致老年人更快,更危险的剖析. 这项研究揭示了依赖年龄的微观结构变化,有助于大动脉剖析进展.

科学领域:

生物医学工程生物医学工程
心血管研究研究心血管研究
材料科学材料科学材料科学

背景情况:

大动脉解剖 (AD) 是一种危及生命的疾病,衰老是一个重要的风险因素.
老龄化损害大动脉解剖阻力的确切机制尚不清楚.
了解这些机制对于开发有效的AD临床管理策略至关重要.

研究的目的:

为了研究人类下降胸前大动脉 (DTAs) 在不同年龄段的多尺度剖析行为.
阐明老化如何影响DTA的机械性能和微观结构完整性.
为了确定与年龄有关的大动脉解剖风险增加的潜在机制.

主要方法:

集成的机械测试,多光子成像和有限元素 (FE) 模型的人类DTA.
在剖析的DTA介质中量化机械性能和分析微结构变化.
开发了一个离散的FE模型来模拟剖析传播和膜间原纤维 (ICF) 失效.

主要成果:

衰老会减少DTA介质内的膜间结合,从而降低解剖阻力.
剖析传播表现出与ICF故障的雪崩相关的权力规律行为.
衰老导致弹性板状组织较差,原纤维较少,ICF分散增加,促进更快的剖析.

结论:

衰老通过微观结构变化显著削弱了大动脉剖析抵抗,特别是在ICF中.
基于年龄的ICF失败的雪崩驱动了在剖析传播中观察到的权力规律行为.
随着年龄的增长,小雪崩的频率增加加快了AD的进展,对老年人构成更大的风险.

关键词:

动脉剖析是一个大动脉剖析.离散的有限元素模型.间叶片纤维纤维是什么?微观结构机制的机制.剥离测试试验剥离测试试验

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