尿类 parabens,先进的糖化终产品和儿童的血压:一个纵向队列研究
Brigitte Reimann1, Hanne Sleurs1, Rossella Alfano1
1Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.
Environmental research
|June 29, 2025
概括
早期暴露于类甲,特别是类甲 (PrP),与晚期糖化终产物 (AGEs) 和儿童血压 (BP) 变化有关. 需要进一步研究心血管健康的长期影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心血管研究研究心血管研究
背景情况:
- 类暴露和先进的糖化终产物 (AGEs) 独立地与诸如高血压等心血管疾病有关.
- 帕拉本暴露与AGE之间的关系,以及它们对血压的综合影响,仍未得到充分研究.
- 素可能通过其增加AGE的潜力影响血压.
研究的目的:
- 为了调查早期生活中对素暴露和儿童的AGE之间的关联.
- 为了检查随着时间的推移对暴露,AGE和血压 (BP) 之间的关系.
- 探索AGEs在暴露和BP之间的关联中扮演的调解角色.
主要方法:
- 对来自ENVIRONAGE出生队列的83名儿童进行了纵向研究.
- 用超高性能液体染色学/并联质谱学测量尿液中素度 (甲基,乙基,基,丁基).
- 血压和皮肤自光 (SAF) 评估了4岁和10岁的AGE.
- 统计分析包括一般化的线性混合模型,量子g计算和结构方程建模 (SEM).
主要成果:
- 在烯混合物和AGEs (β = -0.30) 之间观察到一个反向关联,主要是由烯 (PrP) 驱动的.
- 帕拉本暴露对静脉压的直接影响在4岁时被发现.
- 在10岁时,AGE调解了类暴露对10岁的透静血压的逆间接影响.
结论:
- 早期暴露于类,特别是PrP,与儿童的AGE和血压水平有关.
- 这些发现表明,通过AGE诱导类药物引起的心血管影响的潜在途径.
- 需要进一步研究早期接触的长期健康后果.
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