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Updated: Sep 17, 2025

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GMFOLD:用于高通量DNA - 吸收体二次结构分类和机器学习可解释性的子图匹配

Paolo Climaco1, Noelle M Mitchell2, Matthew J Tyler3

  • 1Institut für Numerische Simulation, University of Bonn, Bonn, 53115, NRW, Germany.

Mathematical biosciences
|June 29, 2025
PubMed
概括

我们开发了GMfold,这是一个Python工具,用于快速预测DNA体二次结构. 这种高通量方法有助于分析来自SELEX的大型体池,推进生物传感器和治疗开发.

关键词:
亚普特美尔 (Aptamer) 是一种药物.这些DNA描述符是DNA描述符.在DNA折叠过程中莫茨金的路径是莫茨金的路径.这就是SELEXEX.频谱聚类是指光谱的聚类.副图匹配的部分图.主题建模 主题建模

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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