皮肤替代材料的表面特性
Alexander Jaekel1, Michaela Wirtz1
1Department of Natural Sciences, University of applied Sciences Bonn-Rhein-Sieg, Rheinbach, Germany.
概括
开发可靠的皮肤替代品对于通过皮肤递送药物的粘附性测试至关重要. 这项研究评估了和VitroSkin等材料,发现它们具有可比的表面功能,但需要进一步增强机械性能.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 制药科学 制药科学
背景情况:
- 通过皮肤进行的治疗系统需要强大的皮肤粘附力,以可靠地输送活性药物成分.
- 目前使用钢材的体外粘附测试方法与体内性能缺乏相关性,需要改进皮肤替代品.
- 由于体外-体外相关性较差,往往需要进行广泛的体内研究,从而增加产品开发成本和时间.
研究的目的:
- 评估和比较各种合成材料的类似皮肤的特性,用于体外粘附测试.
- 建立一个全面的皮肤相似性指数,以评估皮肤替代品的适用性.
- 为开发先进的皮肤替代品提供基线,用于通过皮肤粘附的评估.
主要方法:
- 使用合成皮革, (龙皮),凝和VitroSkin作为皮肤替代材料.
- 使用反射光显微镜和共聚焦光显微镜进行地形分析.
- 应用红外光谱仪用于功能组分析,以及皮肤学探针用于摩擦,pH和弹性测量,加上数据融合.
主要成果:
- 所有测试的替代材料都表现出与人类皮肤具有共同的地形特征,但存在局限性.
- 凝和VitroSkin显示了与人类皮肤相比较的表面功能.
- 在所有测试的替代材料的机械性能中观察到显著的缺陷.
结论:
- 对地形,化学功能和机械性能进行了全面的评估,发现替代品中的不同程度的皮肤相似性.
- 开发的皮肤相似性指数为评估皮肤替代品提供了一种多功能方法.
- 建议进行进一步的研究,结合额外的特性和材料,以提高皮肤替代品在粘附测试中的实用性.
相关概念视频
Clinical Applications of Epidermal Stem Cells
2.8K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.8K
Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K
Cells of the Epidermis
4.6K
The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
4.6K
Changes in Skin Color: Clinical Perspectives
2.3K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.3K
Skin Cancer
4.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.6K
Skin Diseases and Disorders
4.2K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.2K


