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在患有高血压的患者中,原发性阿尔多斯特隆症的患病率
Divyansh Goyal1, Manasvini Bhatt2, Tamoghna Ghosh3
1Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
Clinical endocrinology
|June 30, 2025
概括
在患有基本高血压 (EHTN) 的患者中,主性阿尔多斯特隆症 (PA) 经常被忽视. 这项研究发现,在EHTN患者中,PA的患病率很高,这突显了增加查和诊断的必要性.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 高血压研究 高血压研究
背景情况:
- 原发性阿尔多斯特隆症 (PA) 是二次高血压的一个重要原因.
- 肺炎与心血管疾病发病率和死亡率增加有关.
- 肺炎的患病率仍未得到充分研究,特别是在被诊断为基本高血压 (EHTN) 的患者中.
研究的目的:
- 确定目前正在治疗基本高血压 (EHTN) 的患者中原发性阿尔多斯顿主义 (PA) 的患病率.
主要方法:
- 一项前性,横截面研究涉及492名被诊断患有EHTN的参与者.
- 对PA的查包括测量血阿尔多素度 (PAC) 和直接雷宁度 (DRC) 以计算阿尔多素与雷宁的比率 (ARR).
- 根据内分泌学会的指导方针,使用盐水输液试验 (SIT) 进行确认测试,如果在SIT后的PAC超过5ng/dL,则诊断出PA.
主要成果:
- 在492名EHTN参与者中,18.49% (91人) 的PA查测试结果为阳性.
- 在确认性测试后,PA在总EHTN队列的8.04% (37分之492) 中得到证实.
- 随着高血压等级和每日药物剂量增加,PA的患病率增加,但PA和EHTN组之间的低血没有显著差异.
结论:
- 这项研究显示,在被诊断患有基本高血压的患者中,原发性阿尔多斯特隆症的患病率很高.
- 这些发现强调了在看似基本高血压的个体中对PA进行查的重要性.
- 早期诊断和PA的管理可能会减轻相关的心血管风险.
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