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增强检查点阻塞免疫疗法与T细胞膜氧化还原稳态调节和深度学习增强的NIR-II成像

Ranran Guo^1,2,3, Ruixun Chen¹, Zhenhang Rao¹

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.

Advanced healthcare materials

|June 30, 2025

概括

这项研究引入了一种新的zwitterionic聚合物结合物用于Atezolizumab,增强其传递和T细胞功能,以克服瘤免疫抑制. 这种方法在临床前模型中提高了抗瘤疗效和存活率.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
生物材料科学生物材料科学

背景情况:

免疫检查点阻塞疗法显示出希望,但受到免疫抑制瘤微环境的限制.
瘤中的氧化应激阻碍了抗瘤免疫细胞的功能和治疗的有效性.

研究的目的:

为Atezolizumab的输送设计一个zwitterionic聚合物合物.
为了恢复T细胞氧化还原稳定,并在瘤微环境中增强抗瘤免疫力.
为了可视化和评估抗体结合物的体内动态和治疗疗效.

主要方法:

将阿特佐利祖马布结合到一种兹维特里聚合物,使其无痕释放.
近红外II光成像与深度学习用于体内跟踪.
评估T细胞增殖,氧化还原状态和铁亡缓解.
在大肠直肠癌小鼠模型中评估抗瘤功效.

主要成果:

抗体结合体表现出增强和加速的瘤积累.
结合剂促进了T细胞的增殖和增强了抗瘤功效.
保护T细胞表面氧化还原状态的调节,防止反应性氧物种和缓解的T细胞铁灭.
有效抑制瘤生长和复发,导致小鼠延长存活时间.

结论:

兹维特里聚合物联合物有效地逆转了抑制性瘤微环境.
这种方法通过恢复T细胞功能和减轻铁亡来增强检查点抑制剂疗法.
开发的结合物有望在下一代癌症免疫治疗中临床转化.

关键词:

在NIR-II成像中使用NIR-II成像.的T淋巴细胞.免疫检查点阻塞疗法免疫检查点阻塞疗法膜氧化还原恒温作用.这是一种zwitterionic聚合物.

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