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Updated: Sep 17, 2025

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用计算显微镜解锁DYRK1A激酶的 conformational 秘密:探索酸化驱动的结构动力学

Kapil Dattatray Ursal1, Md Fulbabu Sk2, Subhasmita Mahapatra1

  • 1Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Indore, Madhya Pradesh, India.

Journal of computational chemistry
|June 30, 2025
PubMed
概括

酸化显著影响DYRK1A激酶的结构和动态,影响其激活. 这项研究揭示了酸化如何改变DYRK1A形状,为神经疾病和癌症的向治疗提供了洞察力.

关键词:
DYRK 激酶的作用是什么分子动力学分子动力学神经系统疾病 神经系统疾病酸化的方法是:光化.治疗药物亲和关系 疗法亲和关系

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