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Updated: Sep 17, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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亲属ALS/FTD相关的缺少RNA结合的TDP-43突变导致神经元和突触转录失调 in vitro

Molly Magarotto1, Richard T Gawne1,2, Gabriele Vilkaite1

  • 1Department of Biology and York Biomedical Research Institute, University of York, Wentworth Way, York YO10 5DD,Yorkshire, United Kingdom.

Human molecular genetics
|June 30, 2025
PubMed
概括

在TDP-43 (TAR DNA结合蛋白 43) 中的突变会损害RNA结合,导致ALS和FTD的神经退行. 这项研究表明,这些突变会破坏细胞模型中的神经元分化和基因表达.

关键词:
这是一种RNA结合蛋白质.在TDP-43中使用.骨髓缩侧面硬化症 (ALS) 是一种前性痴呆症前性痴呆症神经退行症的神经退行症

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