在质子疗法中对剂量驱动的连续扫描的时间特征进行全面的描述
Clifford Ghee Ann Chua1,2, Keith M Furutani3, Kang Hao Lee1
1Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore.
Physics in medicine and biology
|June 30, 2025
概括
这项研究全面描述了剂量驱动的持续扫描 (DDCS) 质子疗法的时间性质,揭示了关键参数,如光束电流上升时间和光束点之间的最小时间,以提高系统性能.
科学领域:
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
- 质子疗法是一种治疗方法.
背景情况:
- 时间动态的准确表征对于优化剂量驱动持续扫描 (DDCS) 质子疗法系统至关重要.
- 了解像光束电流上升时间和点间时间等参数对于精确的剂量输送至关重要.
研究的目的:
- 为了全面描述DDCS质子疗法系统的时间性质.
- 量化到标称光束电流 (trise) 的上升时间,断点 (tb) 之间的最小时间,光束电流波动和翻盖剂量.
主要方法:
- 用 Hitachi 质子疗法同步仪进行的测量.
- 使用20kHz的二维条形电离室 (CROSSmini) 评估光束电流波动.
- 使用来自射频淘汰 (RFK),高速切换磁铁 (HSST) 和剂量监控信号的振荡仪数据量化的trise, tb和flap剂量.
主要成果:
- 观察到高达65%的瞬时光束电流波动,在平均化后与日志文件数据进行验证.
- 断裂点之间的最小时间测量为 (1.67 ± 0.04) 毫秒,使用最小的片剂量 (4 μMU).
- 三位数显示对光束电流的依赖性,较低的电流呈现较长的上升时间;日志文件和直接测量相关 (r=0.86).
结论:
- 这项研究提供了DDCS质子疗法系统的第一个全面的时间特征.
- 已建立的方法可以帮助在其他机构调试DDCS质子疗法系统.
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