肠道微生物群:理解和保护临灭绝的高原思索托拉克斯鱼的新前沿
Hongbo Pan1, Haiping Liu1,2,3, Fei Liu1,4
1College of Ecology and Environment, Tibet University, Lhasa, Xizang, China.
Frontiers in microbiology
|June 30, 2025
概括
临灭绝的西藏鱼类的肠道微生物群多样性较低,这表明潜在的健康脆弱性. 饮食显著影响微生物组成,对保护策略至关重要.
科学领域:
- 生态生态学 生态生态学
- 微生物学 微生物学
- 保护生物学 保护生物学
背景情况:
- 全球生物多样性下降需要了解影响危物种的因素.
- 肠道微生物群在保护特有物种,特别是西藏鱼类中的作用在很大程度上是未被探索的.
- 地方性西鱼对高原生态系统至关重要,但面临着严重的生存威胁.
研究的目的:
- 调查肠道微生物群组成与五种特有藏族鱼类的保护状况之间的联系.
- 为了比较微生物多样性,占主导地位的细菌类,以及饮食对这些物种肠道微生物群的影响.
- 探索危物种的基于微生物组的保护策略.
主要方法:
- 16S rRNA测序用于分析肠道微生物群社区结构.
- 系统地比较了微生物多样性,占主导地位的细菌类和饮食影响.
- 鱼类物种包括国家保护的特有物种,如*Oxygymnocypris stewarti*和*Schizothorax waltoni*.
主要成果:
- 状细菌,蛋白质细菌和状微生物是常见的,而状细菌在临灭绝的鱼类中是独一无二的.
- 肠道微生物群的多样性随着危程度的增加而减少 (最不关心>近乎危>脆弱>危).
- 植物食鱼的微生物多样性高于万食鱼和肉食鱼,这证实了饮食的重要影响.
结论:
- 这项研究提供了第一个证据,将肠道微生物群与特有藏族鱼类的保护状况联系起来.
- 危物种中微生物多样性的减少表明了潜在的健康漏洞.
- 饮食策略和息地保护对于管理肠道微生物群和支持危鱼群至关重要.
相关概念视频
Introduction to the Human Microbiota
209
Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
209
The Oral Microbiota
90
The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
90
Microbiota of the Stomach and Small Intestine
77
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
77
Microbiota of the Large Intestine
98
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
98
Functions of the Gut Microbiota
233
The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
233
Gut-Brain Axis
222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222


