维生素摄入量与前列腺癌之间的关联:一个横截面研究
Sen Pan1, Chuanlin Wang1, Wei Sun1
1Department of Urology, Chongqing University Fuling Hospital, Chongqing, China.
Frontiers in nutrition
|June 30, 2025
概括
饮食中摄入较高的网醇增加了前列腺癌 (PCa) 风险,而维生素B1和B2补充剂降低了这一风险. 补充维生素B9和B12的摄入显示了与PCa风险的反向关联.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 维生素是生理功能必需的微量营养素.
- 特定维生素摄入量与前列腺癌 (PCa) 风险之间的关系尚未完全理解.
- 关于维生素对PCa的影响存在矛盾的发现.
研究的目的:
- 调查各种维生素摄入来源 (饮食,补充剂) 与PCa风险之间的关联.
- 探索影响PCa风险的潜在非线性关系和相互作用.
- 提供有关维生素摄入量和PCa预防的最新证据.
主要方法:
- 从NHANES (2007-2018) 中对14977名成年男性进行横截面分析.
- 通过24小时回忆评估的饮食摄入量;使用加权后勤回归和限制立方线 (RCS) 的统计分析.
- 调整了包括年龄,BMI,种族,酒精,吸烟和并发症在内的共同变量.
主要成果:
- 饮食中高摄入的视网醇与PCa风险增加相关 (OR=1.76).
- 补充维生素B1 (OR=0.38) 和维生素B2 (OR=0.35) 的摄入显示出与PCa的反向关联.
- 补充B9,B12和总B12摄入量与PCa风险相反相关;观察到饮食维生素A,B6,B12和C的非线性关联.
结论:
- 饮食中的视网醇和特定的维生素B补充剂摄入量与PCa风险有不同的关联.
- 对维生素B12补充剂的非线性影响和与年龄的相互作用需要进一步研究.
- 需要大规模的随机对照试验来证实这些发现,并指导PCa预防策略.
更多相关视频
07:25A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.3K
12:23Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer
Published on: August 2, 2018
12.3K
相关概念视频
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Cancer Vaccines
517
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
517
Vitamins
1.0K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
1.0K
Observational Studies
9.2K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
9.2K
mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
Study Designs in Epidemiology
431
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
431
