对于高风险的非肌肉侵入性膀癌的新兴膀节约治疗方法
Clarissa M Gurbani1, Yew-Lam Chong1,2,3, Zhen Wei Choo1,2,3
1Department of Urology, Tan Tock Seng Hospital, National Healthcare Group, Singapore, Singapore.
Bladder cancer (Amsterdam, Netherlands)
|June 30, 2025
概括
高风险的非肌肉侵入性膀癌 (HR-NMIBC) 治疗方法正在超越激进囊切除术的发展. 新的膀节约疗法 (BST) 是有前途的,但需要更多的研究才能广泛使用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 膀癌 (BC) 是一个主要的健康问题,非肌肉侵入性膀癌 (NMIBC) 占诊断的75%.
- 高风险NMIBC (HR-NMIBC) 具有挑战性,因为高的复发率和进展率,即使与Bacillus Calmette-Guerin (BCG) 治疗.
- 激进囊切除术虽然有效,但涉及显著的发病率和患者的不情愿,推动寻找替代方案.
研究的目的:
- 对高风险NMIBC的膀节约疗法 (BST) 的不断变化的格局进行审查.
- 突出新兴的BST,包括免疫疗法,基因疗法和设备辅助策略.
- 强调需要进一步临床验证这些新型治疗方法.
主要方法:
- 这是对HR-NMIBC的当前和新兴膀节约疗法的叙述性综述.
- 该审查综合了临床试验和研究新药和设备辅助策略的数据.
- 专注于旨在保持膀功能,同时管理疾病复发和进展的治疗方法.
主要成果:
- 新兴的BST如pembrolizumab,nadofaragene firadenovec和nogapendekin alfa inbakicept显示出有希望的响应率.
- 基因疗法 (例如,CG0070,EG-70) 和设备辅助策略 (例如,高热,电机药物输送) 也在调查中.
- 目前的大多数数据来自早期,单臂研究,需要通过更大的随机试验进行验证.
结论:
- 新型膀节约疗法为HR-NMIBC提供了激进囊切除术的潜在替代方案.
- 进一步强有力的临床证据对于完善患者选择和优化治疗结果至关重要.
- 在实施这些先进疗法时,平衡疗效,安全性和成本效益仍然是一个关键的挑战.
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